Cerebrospinal fluid amyloid status and affective symptoms in mild cognitive impairment
نویسندگان
چکیده
منابع مشابه
Neuropsychological Testing Predicts Cerebrospinal Fluid Amyloid-β in Mild Cognitive Impairment.
BACKGROUND Psychometric tests predict conversion of mild cognitive impairment (MCI) to probable Alzheimer's disease (AD). Because the definition of clinical AD relies on those same psychometric tests, the ability of these tests to identify underlying AD pathology remains unclear. OBJECTIVE To determine the degree to which psychometric testing predicts molecular evidence of AD amyloid patholog...
متن کاملβ-Amyloid (1–42) Levels in Cerebrospinal Fluid and Cerebral Atrophy in Mild Cognitive Impairment and Alzheimer's Disease
BACKGROUND Recent studies consistently reported Alzheimer's disease (AD) and, to a lower extent, mild cognitive impairment (MCI) to be accompanied by reduced cerebrospinal fluid (CSF) levels of β-amyloid. However, how these changes are related to brain morphological alterations is so far only partly understood. METHODS CSF levels of β-amyloid (1-42) were examined with respect to cerebral atro...
متن کاملNeuropsychiatric Symptoms in Mild Cognitive Impairment.
OBJECTIVE Neuropsychiatric symptoms (NPS) may be the first manifestation of an underlying neurocognitive disorder. We undertook a review to provide an update on the epidemiology and etiological mechanisms of NPS that occur in mild cognitive impairment (MCI) and just before the onset of MCI. We discuss common clinical presentations and the implications for diagnosis and care. METHOD The author...
متن کاملNeuropsychiatric symptoms in Mild Cognitive Impairment
Materials and methods A total of 30 subjects, aged more than 60 years old, with either MCI (n = 16) or control group (n = 14) were studied. Neuropsychiatric symptoms (NPS) were assessed using the Neuropsychiatric Inventory scale(NPI). Individual subscores of the 10 NPI symptoms and total NPI scores were compared between the MCI patients and control patients. We identified the prevalence of the ...
متن کاملAmino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment.
BACKGROUND Early identification of patients with mild cognitive impairment (MCI) progressing to Alzheimer disease (MCI-AD) by use of biomarkers in cerebrospinal fluid (CSF) is an essential step toward improving clinical diagnosis and drug development. We evaluated whether different beta-amyloid(42) (Abeta42) peptides can add further information to the combined use of tau and Abeta1-42 for predi...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2020
ISSN: 1552-5260,1552-5279
DOI: 10.1002/alz.041961